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We describe six patients with painful polyneuropathy associated with hyperlipidemia.Each had a mild,slowly progressive neuropathy characterized by pain in feet,without proximal extension or involvement of hands. Weakness and autonomic symptoms and signs were absent.Three patients had normal tendon reflexes;three others had decreased ankle reflexes.Serum cholesterol levels were moderately increased;serum triglyceride levels were exceedingly high.In one patient,symptoms resolved with correction of hypertriglyceridemia.No other cause of peripheral neuropathy was found. Marked increases in serum triglycerides may cause painful small-fiber neuropathy. |
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